Comprehensive Phytochemical Profile of Soy Protein Isolate (2025)

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    • Nianbai Fang
    • Shanggong Yu
    • Thomas M. Badger

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    Arkansas Children's Nutrition Center, and Departments of Pharmaceutical Sciences and Physiology/Biophysics, University of Arkansas for Medical Sciences, 1120 South Marshall Street, Little Rock, Arkansas 72202

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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2004, 52, 12, 4012–4020

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    https://pubs.acs.org/doi/10.1021/jf049842y

    Published May 15, 2004

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    Abstract

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    Although an FDA health claim for soy protein has been issued, the potential health benefits of soy foods remain controversial among scientists, especially with regard to soy infant formula. The UV detectable isoflavones have been the focus of the majority of studies concerning health-related effects of soy protein isolate (SPI). However, the chemical identities and health effects of other SPI phytochemicals without UV absorption properties are less well-studied. In the current study, we employed liquid chromatography−tandem mass spectrometry methods to reveal a complicated phytochemical profile for SPI consisting of 136 phytochemicals. Also, we have quantitated many of these SPI phytochemicals so that dietary intakes can be estimated for foods containing SPI. On a weight/weight basis, fatty acids are the largest group of phytochemicals in the extract (64.13% total fat), followed by saponins (21.48%), and then isoflavones at 6.82%. Of the 56 lysophospholipids identified in SPI, 0.50% was lysophosphatidylcholines and 0.23% was lysophosphatidylethanolamines.

    Keywords: Soy protein; isoflavones; soysaponins; lysophospholipids; fatty acids; LC-MS/MS; folates

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    Copyright © 2004 American Chemical Society

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    • Carbohydrates
    • Flavonoids
    • Lipids
    • Phytochemistry
    • Reaction products

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     Arkansas Children's Nutrition Center.

     Department of Pharmaceutical Sciences.

    *

     To whom correspondence should be addressed. Tel:  501-364-2785. Fax:  501-364-2818. E-mail:  [emailprotected].

    §

     Department of Physiology/Biophysics.

    Cited By

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    4. Mark A. Berhow,, Suk Bin Kong,, Karl E. Vermillion, and, Sandra M. Duval. Complete Quantification of Group A and Group B Soyasaponins in Soybeans. Journal of Agricultural and Food Chemistry 2006, 54 (6) , 2035-2044. https://doi.org/10.1021/jf053072o
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    14. Katrina L. Watson, Kristen Sauerzopf, Roger A. Moorehead. Isolated Soy Protein Promotes Mammary Tumor Development Induced by the Type I Insulin-like Growth Factor Receptor in Transgenic Mice. Nutrition and Cancer 2021, 73 (8) , 1340-1349. https://doi.org/10.1080/01635581.2020.1795210
    15. Linda Yu, Eddy Rios, Lysandra Castro, Jingli Liu, Yitang Yan, Darlene Dixon. Genistein: Dual Role in Women’s Health. Nutrients 2021, 13 (9) , 3048. https://doi.org/10.3390/nu13093048
    16. Abigail Raffner Basson, Saleh Ahmed, Rawan Almutairi, Brian Seo, Fabio Cominelli. Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds. Foods 2021, 10 (4) , 774. https://doi.org/10.3390/foods10040774
    17. Haixia Lin, Mousumi Chaudhury, Neha Sharma, Sudeepa Bhattacharyya, Ahmed A. Elolimy, Laxmi Yeruva, Martin J.J. Ronis, Kelly E. Mercer. MicroRNA profiles were altered in neonatal piglet mammary glands following postnatal infant formula feeding. The Journal of Nutritional Biochemistry 2020, 83 , 108397. https://doi.org/10.1016/j.jnutbio.2020.108397
    18. Kelly E Mercer, Sudeepa Bhattacharyya, Neha Sharma, Mousumi Chaudhury, Haixia Lin, Laxmi Yeruva, Martin J Ronis. Infant Formula Feeding Changes the Proliferative Status in Piglet Neonatal Mammary Glands Independently of Estrogen Signaling. The Journal of Nutrition 2020, 150 (4) , 730-738. https://doi.org/10.1093/jn/nxz273
    19. Guanhao Bu, Ting Huang, Tanghao Li. The separation and identification of the residual antigenic fragments in soy protein hydrolysates. Journal of Food Biochemistry 2020, 44 (3) https://doi.org/10.1111/jfbc.13144
    20. Sadia Hassan, Chukwuebuka Egbuna, Habibu Tijjani, Jonathan C. Ifemeje, Michael Chinedu Olisah, Kingsley C. Patrick-Iwuanyanwu, Precious Chidinma Onyeike, Benson Chukwunweike Ephraim-Emmanuel. Dietary Supplements: Types, Health Benefits, Industry and Regulation. 2020, 23-38. https://doi.org/10.1007/978-3-030-42319-3_3
    21. Roger A. Moorehead. Rodent Models Assessing Mammary Tumor Prevention by Soy or Soy Isoflavones. Genes 2019, 10 (8) , 566. https://doi.org/10.3390/genes10080566
    22. Anne-Gaëlle Sicaire, Frédéric Fine, Alain Quinsac, Meriem Boukroufa, Njara Rakotomanomana, Farid Chemat. Innovative Techniques and Alternative Solvents for Green Extraction of Proteins from Pulses and Oleaginous Meals as Industrial Sources for Food and Feed. 2019, 237-256. https://doi.org/10.1007/978-981-13-3810-6_9
    23. S. Hüser, S. Guth, H. G. Joost, S. T. Soukup, J. Köhrle, L. Kreienbrock, P. Diel, D. W. Lachenmeier, G. Eisenbrand, G. Vollmer, U. Nöthlings, D. Marko, A. Mally, T. Grune, L. Lehmann, P. Steinberg, S. E. Kulling. Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation. Archives of Toxicology 2018, 92 (9) , 2703-2748. https://doi.org/10.1007/s00204-018-2279-8
    24. Martin JJ Ronis, Horacio Gomez-Acevedo, Kartik Shankar, Neha Sharma, Michael Blackburn, Rohit Singhal, Kelly E Mercer, Thomas M Badger. Soy protein isolate feeding does not result in reproductive toxicity in the pre-pubertal rat testis. Experimental Biology and Medicine 2018, 243 (8) , 695-707. https://doi.org/10.1177/1535370218771333
    25. Martin J.J. Ronis, Kim B. Pedersen, James Watt. Adverse Effects of Nutraceuticals and Dietary Supplements. Annual Review of Pharmacology and Toxicology 2018, 58 (1) , 583-601. https://doi.org/10.1146/annurev-pharmtox-010617-052844
    26. K. E. Mercer, C. F. Pulliam, L. Hennings, M. A. Cleves, E. E. Jones, R. R. Drake, M. J. J. Ronis. Diet Supplementation with Soy Protein Isolate, but Not the Isoflavone Genistein, Protects Against Alcohol-Induced Tumor Progression in DEN-Treated Male Mice. 2018, 115-126. https://doi.org/10.1007/978-3-319-98788-0_9
    27. Gianluca Rizzo, Luciana Baroni. Soy, Soy Foods and Their Role in Vegetarian Diets. Nutrients 2018, 10 (1) , 43. https://doi.org/10.3390/nu10010043
    28. Eman Shawky, Shaimaa M Sallam. Simultaneous Determination of Soyasaponins and Isoflavones in Soy (Glycine max L.) Products by HPTLC-densitometry-Multiple Detection. Journal of Chromatographic Science 2017, 55 (10) , 1059-1065. https://doi.org/10.1093/chromsci/bmx062
    29. Wei Feng, Qiuju Dong, Minyan Liu, Si Li, Ting Liu, Xinguo Wang, Liying Niu. Screening and identification of multiple constituents and their metabolites of Zhi‐zi‐chi decoction in rat urine and bile by ultra‐high‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry. Biomedical Chromatography 2017, 31 (10) https://doi.org/10.1002/bmc.3978
    30. Sae Bom Won, Anna Han, Young Hye Kwon. Maternal consumption of low-isoflavone soy protein isolate alters hepatic gene expression and liver development in rat offspring. The Journal of Nutritional Biochemistry 2017, 42 , 51-61. https://doi.org/10.1016/j.jnutbio.2016.12.013
    31. Umar Lawal, Sze Wei Leong, Khozirah Shaari, Intan Safinar Ismail, Alfi Khatib, Faridah Abas. α-Glucosidase Inhibitory and Antioxidant Activities of Different Ipomoea aquatica Cultivars and LC-MS/MS Profiling of the Active Cultivar. Journal of Food Biochemistry 2017, 41 (2) , e12303. https://doi.org/10.1111/jfbc.12303
    32. Kelly E Mercer, Casey F Pulliam, Kim B. Pedersen, Leah Hennings, Martin JJ Ronis. Soy protein isolate inhibits hepatic tumor promotion in mice fed a high-fat liquid diet. Experimental Biology and Medicine 2017, 242 (6) , 635-644. https://doi.org/10.1177/1535370216685436
    33. Meryem Boukroufa, Anne-Gaëlle Sicaire, Frederic Fine, Colette Larré, Aude Goff, Véronique Jamault, Njara Rakotomanomana, Farid Chemat. Green Sonoextraction of Protein from Oleaginous Press Rapeseed Cake. Molecules 2017, 22 (1) , 80. https://doi.org/10.3390/molecules22010080
    34. Mark Messina. Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature. Nutrients 2016, 8 (12) , 754. https://doi.org/10.3390/nu8120754
    35. Martin J. J. Ronis. Effects of soy containing diet and isoflavones on cytochrome P450 enzyme expression and activity. Drug Metabolism Reviews 2016, 48 (3) , 331-341. https://doi.org/10.1080/03602532.2016.1206562
    36. Dong-Gu Oh, Yu Kyung Jang, Jie Eun Woo, Jong-Sang Kim, Choong Hwan Lee. Metabolomics reveals the effect of garlic on antioxidant- and protease-activities during Cheonggukjang (fermented soybean paste) fermentation. Food Research International 2016, 82 , 86-94. https://doi.org/10.1016/j.foodres.2016.01.019
    37. Martin J. Ronis, Horacio Gomez-Acevedo, Michael L. Blackburn, Mario A. Cleves, Rohit Singhal, Thomas M. Badger. Uterine responses to feeding soy protein isolate and treatment with 17β-estradiol differ in ovariectomized female rats. Toxicology and Applied Pharmacology 2016, 297 , 68-80. https://doi.org/10.1016/j.taap.2016.02.019
    38. Aizhan Sabirzhanovna Turmagambetova, Nadezhda Sergeevna Sokolova, Andrey Pavlinovich Bogoyavlenskiy, Vladimir Eleazarovich Berezin, Mary Ann Lila, Diana M. Cheng, Vyacheslav Dushenkov. New functionally-enhanced soy proteins as food ingredients with anti-viral activity. VirusDisease 2015, 26 (3) , 123-132. https://doi.org/10.1007/s13337-015-0268-6
    39. Milena Masullo, Paola Montoro, Angela Mari, Cosimo Pizza, Sonia Piacente. Medicinal plants in the treatment of women's disorders: Analytical strategies to assure quality, safety and efficacy. Journal of Pharmaceutical and Biomedical Analysis 2015, 113 , 189-211. https://doi.org/10.1016/j.jpba.2015.03.020
    40. Ye Rim Nam, Sae Bom Won, Young-Shin Chung, Chung Shil Kwak, Young Hye Kwon. Inhibitory effects of Doenjang , Korean traditional fermented soybean paste, on oxidative stress and inflammation in adipose tissue of mice fed a high-fat diet. Nutrition Research and Practice 2015, 9 (3) , 235. https://doi.org/10.4162/nrp.2015.9.3.235
    41. Su Yun Lee, Sarah Lee, Sunmin Lee, Ji Young Oh, Eun Jung Jeon, Hyung Seok Ryu, Choong Hwan Lee. Primary and secondary metabolite profiling of doenjang, a fermented soybean paste during industrial processing. Food Chemistry 2014, 165 , 157-166. https://doi.org/10.1016/j.foodchem.2014.05.089
    42. Juan Yang, Jian Guo, Xiao-Quan Yang, Na-Na Wu, Jin-Bo Zhang, Jun-Jie Hou, Yuan-Yuan Zhang, Wu-Kai Xiao. A novel soy protein isolate prepared from soy protein concentrate using jet-cooking combined with enzyme-assisted ultra-filtration. Journal of Food Engineering 2014, 143 , 25-32. https://doi.org/10.1016/j.jfoodeng.2014.06.031
    43. Nívea D. Fonseca, Marcos Paulo Melo Villar, Carmen Marino Donangelo, Daniel Perrone. Isoflavones and soyasaponins in soy infant formulas in Brazil: Profile and estimated consumption. Food Chemistry 2014, 143 , 492-498. https://doi.org/10.1016/j.foodchem.2013.07.126
    44. Isabelle R. Miousse, Neha Sharma, Michael Blackburn, Jamie Vantrease, Horacio Gomez-Acevedo, Leah Hennings, Kartik Shankar, Mario A. Cleves, Thomas M. Badger, Martin J. J. Ronis. Feeding soy protein isolate and treatment with estradiol have different effects on mammary gland morphology and gene expression in weanling male and female rats. Physiological Genomics 2013, 45 (22) , 1072-1083. https://doi.org/10.1152/physiolgenomics.00096.2013
    45. Srinivasan Damodaran, Akshay Arora. Off-Flavor Precursors in Soy Protein Isolate and Novel Strategies for their Removal. Annual Review of Food Science and Technology 2013, 4 (1) , 327-346. https://doi.org/10.1146/annurev-food-030212-182650
    46. Ren Liu, Shilin Liu, Hua Zhou, Cheng Yang, Xiaoya Liu. Completely green synthesis of Ag nanoparticles stabilized by soy protein isolate under UV irradiation. Journal of Wuhan University of Technology-Mater. Sci. Ed. 2012, 27 (5) , 852-856. https://doi.org/10.1007/s11595-012-0561-9
    47. Connie M. Weaver, D. Lee Alekel, Wendy E. Ward, Martin J. Ronis. Flavonoid Intake and Bone Health. Journal of Nutrition in Gerontology and Geriatrics 2012, 31 (3) , 239-253. https://doi.org/10.1080/21551197.2012.698220
    48. Diandian Shen, Qingli Wu, William J. Sciarappa, James E. Simon. Chromatographic fingerprints and quantitative analysis of isoflavones in Tofu-type soybeans. Food Chemistry 2012, 130 (4) , 1003-1009. https://doi.org/10.1016/j.foodchem.2011.07.121
    49. Rong-Xia Guan, Xu-Qian Fang, Ru-Zhen Chang, Li-Juan Qiu. Hypoallergenic Soybean, from Genes to Cultivar. 2012, 347-358. https://doi.org/10.1007/978-3-642-31609-8_21
    50. So-Young Lee, Ju-Sun Kim, Sang-Hee Shim, Sam-Sik Kang. Soyasaponins from Soybean Flour Medium for the Liquid Culture of Ganoderma applanatum. Bulletin of the Korean Chemical Society 2011, 32 (10) , 3650-3654. https://doi.org/10.5012/bkcs.2011.32.10.3650
    51. Jonathan Friedman, Cheryl Frye. Anti-anxiety, cognitive, and steroid biosynthetic effects of an isoflavone-based dietary supplement are gonad and sex-dependent in rats. Brain Research 2011, 1379 , 164-175. https://doi.org/10.1016/j.brainres.2010.12.025
    52. J.-F. Michiels, J. Barbau, S. De Boel, S. Dessy, S.N. Agathos, Y.-J. Schneider. Characterisation of beneficial and detrimental effects of a soy peptone, as an additive for CHO cell cultivation. Process Biochemistry 2011, 46 (3) , 671-681. https://doi.org/10.1016/j.procbio.2010.11.012
    53. Martin J.J. Ronis, Ying Chen, Xioli Liu, Michael L. Blackburn, Kartik Shankar, Reid D. Landes, Nianbai Fang, Thomas M. Badger. Enhanced Expression and Glucocorticoid-Inducibility of Hepatic Cytochrome P450 3A Involve Recruitment of the Pregnane-X-Receptor to Promoter Elements in Rats Fed Soy Protein Isolate. The Journal of Nutrition 2011, 141 (1) , 10-16. https://doi.org/10.3945/jn.110.127423
    54. Leena Hilakivi-Clarke, Juan E. Andrade, William Helferich. Is Soy Consumption Good or Bad for the Breast?. The Journal of Nutrition 2010, 140 (12) , 2326S-2334S. https://doi.org/10.3945/jn.110.124230
    55. Martin J Ronis, Jamie Badeaux, Ying Chen, Thomas M Badger. Rice protein isolate improves lipid and glucose homeostasis in rats fed high fat/high cholesterol diets. Experimental Biology and Medicine 2010, 235 (9) , 1102-1113. https://doi.org/10.1258/ebm.2010.010039
    56. Marguerite A. Klein, Richard L. Nahin, Mark J. Messina, Jeanne I. Rader, Lilian U. Thompson, Thomas M. Badger, Johanna T. Dwyer, Young S. Kim, Carol H. Pontzer, Pamela E. Starke-Reed, Connie M. Weaver. Guidance from an NIH Workshop on Designing, Implementing, and Reporting Clinical Studies of Soy Interventions. The Journal of Nutrition 2010, 140 (6) , 1192S-1204S. https://doi.org/10.3945/jn.110.121830
    57. Martin J. Ronis, Ying Chen, Jamie Badeaux, Thomas M. Badger. Dietary Soy Protein Isolate Attenuates Metabolic Syndrome in Rats via Effects on PPAR, LXR, and SREBP Signaling. The Journal of Nutrition 2009, 139 (8) , 1431-1438. https://doi.org/10.3945/jn.109.107029
    58. Hideki Arimochi, Kyoji Morita, Shusuke Nakanishi, Keiko Kataoka, Tomomi Kuwahara. Production of apoptosis-inducing substances from soybean protein by Clostridium butyricum: Characterization of their toxic effects on human colon carcinoma cells. Cancer Letters 2009, 277 (2) , 190-198. https://doi.org/10.1016/j.canlet.2008.12.006
    59. Thomas M Badger, Janet M Gilchrist, R Terry Pivik, Aline Andres, Kartik Shankar, Jin-Ran Chen, Martin J Ronis. The health implications of soy infant formula. The American Journal of Clinical Nutrition 2009, 89 (5) , 1668S-1672S. https://doi.org/10.3945/ajcn.2009.26736U
    60. Wei Li, Xueyan Bi, Kun Wang, Dongxia Li, Tadaaki Satou, Kazuo Koike. Triterpenoid saponins from Impatiens siculifer. Phytochemistry 2009, 70 (6) , 816-821. https://doi.org/10.1016/j.phytochem.2009.03.022
    61. Shanggong Yu, Qinglin Li, Thomas M. Badger, Nianbai Fang. Quantitative Analysis of Polar Lipids in the Nanoliter Level of Rat Serum by Liquid Chromatography/Mass Spectrometry/Mass Spectrometry. Experimental Biology and Medicine 2009, 234 (2) , 157-163. https://doi.org/10.3181/0807-RM-224
    62. Rohit Singhal, Thomas M. Badger, Martin J. Ronis. Estrogenic status modulates the effect of soy on hepatic responses to 7,12-dimethylbenz(a)anthracene (DMBA). Toxicology and Applied Pharmacology 2009, 234 (1) , 89-97. https://doi.org/10.1016/j.taap.2008.09.027
    63. Jin-Ran Chen, Rohit Singhal, Oxana P. Lazarenko, Xiaoli Liu, William R. Hogue, Thomas M. Badger, Martin J. J. Ronis. Short Term Effects on Bone Quality Associated with Consumption of Soy Protein Isolate and Other Dietary Protein Sources in Rapidly Growing Female Rats. Experimental Biology and Medicine 2008, 233 (11) , 1348-1358. https://doi.org/10.3181/0802-RM-63
    64. T. M. Badger, M. J. J. Ronis, G. Wolff, S. Stanley, M. Ferguson, K. Shankar, P. Simpson, C.-H. Jo. Soy Protein Isolate Reduces Hepatosteatosis in Yellow A vy /a Mice Without Altering Coat Color Phenotype. Experimental Biology and Medicine 2008, 233 (10) , 1242-1254. https://doi.org/10.3181/0802-RM-60
    65. Terence Dwyer, Kristen L Hynes, Jayne L Fryer, C Leigh Blizzard, Fabien S Dalais. The lack of effect of isoflavones on high-density lipoprotein cholesterol concentrations in adolescent boys: a 6-week randomised trial. Public Health Nutrition 2008, 11 (9) , 955-962. https://doi.org/10.1017/S1368980007000869
    66. Rohit Singhal, Thomas M. Badger, Martin J. Ronis. Rats fed soy protein isolate (SPI) have impaired hepatic CYP1A1 induction by polycyclic aromatic hydrocarbons as a result of interference with aryl hydrocarbon receptor signaling. Toxicology and Applied Pharmacology 2008, 227 (2) , 275-283. https://doi.org/10.1016/j.taap.2007.11.009
    67. Martin Kussmann, Michael Affolter, Kornél Nagy, Birgit Holst, Laurent B. Fay. Mass spectrometry in nutrition: Understanding dietary health effects at the molecular level. Mass Spectrometry Reviews 2007, 26 (6) , 727-750. https://doi.org/10.1002/mas.20147
    68. S. Kerre. Anaphylactic reaction to a soja dietary drink in a birch pollen allergic patient. Revue Française d'Allergologie et d'Immunologie Clinique 2007, 47 (6) , 416-417. https://doi.org/10.1016/j.allerg.2007.05.007
    69. Carlo Clerici, Kenneth D.R. Setchell, Pier Maria Battezzati, Matteo Pirro, Vittorio Giuliano, Stefania Asciutti, Danilo Castellani, Elisabetta Nardi, Giuseppe Sabatino, Stefano Orlandi, Monia Baldoni, Olivia Morelli, Elmo Mannarino, Antonio Morelli. Pasta Naturally Enriched with Isoflavone Aglycons from Soy Germ Reduces Serum Lipids and Improves Markers of Cardiovascular Risk. The Journal of Nutrition 2007, 137 (10) , 2270-2278. https://doi.org/10.1093/jn/137.10.2270
    70. Delbert M Gatlin, Frederic T Barrows, Paul Brown, Konrad Dabrowski, T Gibson Gaylord, Ronald W Hardy, Eliot Herman, Gongshe Hu, Åshild Krogdahl, Richard Nelson, Kenneth Overturf, Michael Rust, Wendy Sealey, Denise Skonberg, Edward J Souza, David Stone, Rich Wilson, Eve Wurtele. Expanding the utilization of sustainable plant products in aquafeeds: a review. Aquaculture Research 2007, 38 (6) , 551-579. https://doi.org/10.1111/j.1365-2109.2007.01704.x
    71. Mark Messina, Branin Lane. Soy protein, soybean isoflavones and coronary heart disease risk: Where do we stand?. Future Lipidology 2007, 2 (1) , 55-74. https://doi.org/10.2217/17460875.2.1.55
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    73. Jane Hubert, Monique Berger, Jean Daydé. Validation of a High‐performance Liquid Chromatography‐Ultraviolet Method to Quantify Soy Sapogenols A and B in Soy Germs from Different Cultivars and in Soy Isoflavone‐Enriched Supplements. Journal of Food Science 2005, 70 (8) https://doi.org/10.1111/j.1365-2621.2005.tb11503.x
    74. Shannon Wilson, Kristen Blaschek, Elvira Gonzalez Mejia. Allergenic Proteins in Soybean: Processing and Reduction of P34 Allergenicity. Nutrition Reviews 2005, 63 (2) , 47-58. https://doi.org/10.1111/j.1753-4887.2005.tb00121.x

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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2004, 52, 12, 4012–4020

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    Published May 15, 2004

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